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Lynch syndrome results from germline mutations in DNA mismatch repair genes (MSH2, MLH1, MSH6, PMS2) or epigenetic MSH2 inactivation via EPCAM deletion. Epigenetic MLH1 promoter methylation, the main cause of sporadic colorectal cancer with microsatellite instability, has unclear mechanisms. BRAF V6...

Colorectal Cancer Screening has already proven to be able to reduce CRC mortality in many studies, however, there are still issues in implementation of the screening method. 1.    Compliance rate remains in Asia. Why and what are the keys to improve this?2.    As t...

In public ICUs, where resources are often limited and patient demand is high, triage decisions typically adhere to strict utilitarian principles-prioritizing individuals with the greatest likelihood of survival and long-term benefit. To allocate scarce resources fairly and efficiently, triage framew...