In this presentation, I will discuss the transformative impact of AI on ophthalmology, tracing the journey from initial research concepts to practical clinical applications. We will delve into the specific barriers, such as technical, economic, and logistical challenges, that hinder clinical adoption of AI. Additionally, I will propose strategies to overcome these obstacles and outline the development of AI-powered IT infrastructure for real-world implementation, focusing on clinical workflows and data security measures. The presentation will conclude with a look at future directions in this field, highlighting the importance of ongoing innovation and learning to enhance patient care and improve healthcare systems.